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Physical state of drugs precipitated in confined spaces

This project aims to explore the physical state of APIs within mesoporous magnesium carbonate (MMC) pores using X-ray beams. The investigations aim to uncover mechanisms driving drug precipitation, providing essential insights into release behavior. These findings have the potential to refine drug delivery systems and optimize therapeutic efficacy.

In this project Disruptive Pharma, a pioneering pharmaceutical company, partners with RISE to study the physical state of APIs precipitated within the pores of MMC using nano-focused X-ray beams. Synchrotron facilities such as MAX IV (Sweden), ESRF (France) or DLS (UK) offer unique capabilities to explore the structural characteristics of these confined systems. 

By examining mechanisms that drive drug precipitation one can unravel critical insights into drug stability, solubility, and release behaviour which can open a wide range of opportunities for pharmaceutical research and development. 

It is expected that the results of these experiments will increase the potential to refine drug delivery systems, enhance bioavailability, and adjust therapeutic efficacy. The interplay between the synchrotron technology and pharmaceutical science creates opportunities for innovative formulations, ensuring that specific interactions between API and porous matrices are deciphered. 

Summary

Project name

NANO-DRUGS

Status

Active

Region

Region Stockholm

RISE role in project

Koordinator

Project start

Duration

2 år

Total budget

2 140 000 SEK

Partner

Disruptive Pharma AB

Funders

Vinnova

Coordinators

Project members

Petru Niga

Contact person

Petru Niga

Forskare

+46 10 516 60 26

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Simone Sala

Contact person

Simone Sala

Forskare

+46 10 228 49 32

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