Microscopy analysis of biological surfaces

Do you have a material with antimicrobial effects that you wish to evaluate visually over time? Or do you want to evaluate the effect of a specific substance on, for example, cells or tissues? We have the capability to analyze surfaces with, for example, bacteria or cells and use staining of various markers to answer your specific question.

Fluorescence image of bacteria on surfaces stained with live/dead-staining, where green indicates living and red indicates dead bacteria. The image on the right has significantly fewer living bacteria, indicating antimicrobial properties on the surface.

At RISE, we have access to various bright field and fluorescence microscopes, allowing us to analyze different types of surfaces. By using different stains, specific parts of bacteria or cells can be detected and compared with various treatments. Examples of questions we can help you answer:

For antimicrobial materials, a live/dead staining can be used to estimate the antimicrobial effect of the substance on the surface.
We also have the capability to culture cells from various cell lines and evaluate growth with trypan blue staining, or by detecting different markers typical for, for example, migration and proliferation using various types of antibody staining with fluorescent markers.
We can also analyze sectioned tissue samples from in vivo experiments to detect different markers for, for example, inflammation or similar conditions.
We can also offer FISH analysis (Fluorescence in situ hybridization) and have expertise in karyotyping. FISH is a molecular cytogenetic analysis where specific genes are labeled with a fluorescent probe to detect, for example, loss, duplications, and translocations of chromosomal material.

The projects are tailored entirely to the customer’s needs and wishes. Feel free to contact us to learn more!