Ulla Elofsson
Assoc. Professor
Contact UllaNew publication: investigating thermally induced aggregation
29 May 2023, 16:52
Therapeutic proteins are a growing segment in the pharmaceutical industry. However, one challenge is the formation of protein aggregates. Due to the broad range in size, concentration, and shape, it is necessary to use a combination of techniques for the characterization.
By combining scattering (DLS), fractionation (AF4), and imaging (MiniTEM™) it was possible to show that Somatropin followed a two-step aggregation pathway at pH 7 during heating. First, small, elongated aggregates were formed that, in the second step, clustered together to form larger, more complex aggregates.
The addition of an imaging technique to illustrate the aggregates was shown to be powerful in combination with DLS and AF4 to describe the aggregation pathway for aggregates <100 nm.
Link to the publication, published in International Journal of Pharmaceutics: Investigating thermally induced aggregation of Somatropin- new insights using orthogonal techniques
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